In this paper, the rolling force and reduction ratio have been investigated in multilayer strip rolling. For this purpose, two different set of multilayers have been selected which are Al/St/Al and Cu/Al/Cu layouts. At first, the validation of the numerical analysis was performed by using an experimental test. After validation of the numerical results, two set of multilayer layouts were simulated and the total rolling force and the reduction ratio of each layer have been obtained. Finally, the effect of friction factor between the strip and the roll on the rolling force and reduction ratio has been studied. The results show that stiffness of each layer and the thickness ratio (clad to core) have significant effects on the layers thickness reduction. Also by increasing the friction factor between roll and strip, the clad thickness reduction is decreased and the core thickness reduction and rolling force will be increased.